Home Medication antibacterial
Home Medication antibacterial

benzylpenicilline

J - Antiinfectives For Systemic Use -> J01 - Antibacterials For Systemic Use -> J01C - Beta-Lactam Antibacterials, Penicillins -> J01CE - Beta-Lactamase Sensitive Penicillins -> J01CE01 - Benzylpenicillin
Administration category: Free Medicine group: antibacterial

Safety margins

≥ 18 years
Weight ROA Dosage
ROA:
 iv 		Dosage:
 min. 1million. IU 4 dd to max. 4million. IU 6 dd
ROA:
 iv 		Dosage:
 min. 4million. IU to max. 24million. IU continuous per 24 hours
Comments:

Standaarddosis bij verdenking endocarditis of meningitis: 12 milj EH/24h met 3 milj EH oplaaddosis. Standaarddosis bij overige indicaties: 6 milj EH/24h met 2 milj EH oplaaddosis.

Dosage for "I" sensitivity

≥ 18 years
Weight ROA Load Dosage
ROA:
 iv 		Load:
 - 		Dosage:
 min. 8million. IU/24h to max. 12million. IU/24h

Kidney function

≥ 18 years
ROA GFR Dosage Interval Comments
ROA: iv
GFR:
 10 - 20 		Comments:
 maximaal 12 milj EH/24h
GFR:
 <10 		Comments:
 maximaal 6 milj EH/24h
Renal elimination: 65%
Dosage: dependent on kidney function

Renal function-replacement therapy

CAPD: Bij verminderde nierfunctie is de halfwaardetijd van benzylpenicilline verlengd. Het effect van peritoneale dialyse op de klaring van benzylpenicilline is onbekend.

Hemo dialysis: Endocarditis: 6 milj EH/24 uur als continue infusie. Overige indicaties: 3 milj EH/24 uur als continue infusie.

Pregnancy

Due to the expiration of the alphanumeric classification for use in pregnancy and lactation, reference is made to the current, online information of the Teratology Information Service (TIS) of LAREB:

For individual advice, consult an expert on site.

General comments

Bron: Renal drug handbook

Metadata

Swab vid: M-502768.1
Updated: 09/16/2025 - 17:29
Status: Published

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