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mediastinitis

Advices

≥ 18 years

Indications: Na perforatie tractus digestivus

Priority Medication Remarks
Medication:

amoxicilline + clavulaanzuur iv 1000/200mg 3dd 2 to 6 weeks

+

amoxicilline iv 1000mg 3dd 2 to 6 weeks

Remarks:

Community-accquired. 

Om en om Augmentin/amoxicilline, dus 3 dd Augmentin 1200 mg en 3 dd amoxicilline 1000 mg. 

Medication:

benzylpenicilline iv 1million. IU 6dd 2 to 6 weeks

+

metronidazol iv 500mg 3dd 2 to 6 weeks

Remarks:

Community-accquired

Medication:

ceftriaxon iv 2000mg 1dd 2 to 6 weeks

+

metronidazol iv 500mg 3dd 2 to 6 weeks

Remarks:

Hospital-acquired of postoperatief

≥ 18 years

Indications: Postoperatief na sternotomie

Priority Medication Remarks
Medication:

cefuroxim iv 1500mg 3dd 2 to 6 weeks

Remarks:

Versmallen op geleide van kweek. 

Medication:

flucloxacilline iv 2g 6dd 2 to 6 weeks

or

flucloxacilline iv loading dose 2g, 12g continuous per 24 hours 2 to 6 weeks

General comments

Op geleide van kweek wordt therapie aangepast

Sources

  1. Pubmed.gov publication # 31306791

    Pastene B, et al. Mediastinitis in the intensive care unit patient: a narrative review. Clin Microbiol Infect. 2020 Jan;26(1):26-34.

Antimicrobial resources

The following antimicrobial agents have been used in these recommendations:

External antimicrobial resources
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Metadata

Swab vid: G-502486.1
Updated: 10/24/2024 - 15:06
Status: Published